Pharmacokinetics of linezolid inpatients with continuous renal replacement therapy
10.13699/j.cnki.1001-6821.2014.09.009
- VernacularTitle:利奈唑胺在连续肾替代治疗患者中的药代动力学研究
- Author:
Lei GUO
1
;
Bi-Huan CHENG
;
Zeng-Shou WANG
;
Bing-Yu YING
;
Cheng-Ke HUANG
Author Information
1. 温州医科大学 附属第二医院
- Keywords:
linezolid;
continuous renal replacement therapy;
HPLC;
pharmacokinetics
- From:
The Chinese Journal of Clinical Pharmacology
2014;(9):780-782
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics of linezolid in the patients with continuous renal replacement therapy ( CRRT ).Methods Each of 10 patients with CRRT was given a dose of 600 mg of linezolid with iv during 0.5 h.Plasma samples were collected at different time points after administration of drugs.The concentrations of linezolid in plasma were measured by HPLC.The software of DAS 3.0 was used to determine the pharmacokinetic parameters.Results Two-compartment model was the best to describe the linezolid concentration -time relation when given intravenolisly.The pharmacokinetic parameters of linezolid in 10 patients with CRRT were follows:t1/2 was (4.13 ±0.92) h, Cmax was (16.09 ±2.21)mg· L-1, AUC0-t was (80.05 ±17.89)mg· L-1· h-1.Conclusion There was difference on the pharmacokinetic parameters of linezolid between the patients with CRRT and the normal volunteers.
