Relationship between the dopamine D2 receptor gene polymorphism and efficacy of paliperidone extended release tablets
10.13699/j.cnki.1001-6821.2014.09.005
- VernacularTitle:多巴胺D2受体基因多态性与帕利哌酮缓释片疗效的相关性
- Author:
Xiang-Lai LIU
1
;
Sheng HUANG
;
Zhan LIN
;
Zai-Ji ZHENG
;
Xiong CHEN
Author Information
1. 海南省安宁医院 三科
- Keywords:
schizophrenia;
dopamine D 2 receptor;
gene polymorphism;
pailperidone extended -release tablets;
efficacy
- From:
The Chinese Journal of Clinical Pharmacology
2014;(9):767-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the dopa-mine D2 receptor ( DRD2 ) gene polymorphism and efficacy of paliperi-done extended release tablets.Methods Eighty schizophrenia patients ( the Han nationality ) were included in the study.They were administra-ted with pailperidone extended -release tablets(6-12 mg· d-1 ) for six weeks and assessed with positive and negative symptoms scale ( PANSS) and the other four kinds of scores before and after treatment.They were divided into responsive group ( the reduction rate ≥50%) and unrespon-sive group ( the reduction rate <50%) by the score of PANSS reduction rate.The polymerase chain reaction restriction fragment length polymor-phism ( PCR-RFLP) method was used to determine the relation between DRD2 gene polymorphism and efficacy of paliperidone extended release tablets.Results There were significant differences before and after treatment according to PANSS score and the other four kinds of scores ( P<0.01).The differences of alleles and genotypes frequencies in the responsive group and unresponsive group were not statistically significant ( P>0.05).Conclusion DRD2 gene polymorphism and the efficacy of paliperidone extended -release tablets in Han nationality patients with schizophrenia may be not related .
