Effect of Shenfu injection on blood pressure and heart rate during and after carotid artery stenting
10.13699/j.cnki.1001-6821.2014.09.002
- VernacularTitle:参附注射液在颈动脉支架置入术中及术后对血压和心率的影响
- Author:
Rui-Ming FAN
1
;
Sheng-Tao YAO
;
Gang LI
;
Chang-Ming WANG
;
You-Chao ZENG
;
Song JIAO
;
Xiang-Ping XIA
;
Chong HAN
;
Wei CHEN
;
Zhong-Qiong CHEN
;
Ping XU
;
Qi-Hai GONG
Author Information
1. 遵义医学院 附属医院
- Keywords:
carotid artery stenting;
Shenfu injection;
blood pressure;
heart rate
- From:
The Chinese Journal of Clinical Pharmacology
2014;(9):759-761
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Shenfu injection on blood pressure and heart rate of patients receiving carotid artery stenting.Methods One hundred and twenty patients were randomly divided into the treatment group and the control group , sixty cases in each group.The control group received conventional medication under custodial care , and the treatment group was given Shenfu ( 1 mL · kg -1 ) 10 minutes before surgery.Mean arterial pressure(MAP), heart rate (HR), oxygen satu-ration (SpO2), as well as the frequency of intra -operative hypotension, and the applications of ephedrine and atropine were recorded respectively at the beginning of surgery , the 30 th minute during surgery , the end of surgery and 24 hours after the surgery.Results The operations were all successful , and no adverse reactions occurred.MAP in treatment group at the 30th minute during surgery was higher than in the control group , while it was lower than of the control group at the end of surgery ( P<0.01).HR in the treatment group (68.25 ±7.35) times· min-1 was lower than that of the control group (73.28 ±10.43)times· min-1 at the end of surgery (P<0.05 ).Conclusion Shenfu injection helps stabilize blood pressure and heart rate of patients receiving carotid artery stenting through the two-way adjustment , and it could reduce the occurrence of cerebrovascu-lar accident during the per -operative period.
