Effects of valsartan on blood pressure and insulin sensitivity in aged patients with isolated systolic hypertension
- VernacularTitle:缬沙坦治疗老年单纯收缩期高血压的临床疗效及其对胰岛素抵抗的影响
- Author:
Li HAN
1
;
Zhi-Hua DENG
Author Information
1. 泰达国际心血管病医院 内科
- Keywords:
valsartan;
isolated systolic hypertension;
insulin resistance
- From:
The Chinese Journal of Clinical Pharmacology
2014;(8):661-663
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate clinical efficacy of valsartan on the blood pressure and insulin sensitivity in aged patients with isolated systol-ic hypertension (ISH).Methods Eight -nine patients with ISH were recruited for the prospect clinical trials .All the patients were given val-sartan 80 mg· d-1 for two month.The blood pressure ( BP) , fasting in-sulin ( FINS ) , insulin sensitive index ( ISI ) and related side effects of this drug were all recorded in the procedure of treatment.Results Eighty-one patients finished the clinical trial.The blood pressure began to decrease after one -week administration and the blood pressure was significantly decreased at the end of the trial compared with the initial condition ( P<0.05 ).The fasting insulin levels and insulin sensitivity indexes were significantly decreased after two -month treatment ( P <0.05 ).Four cases of dizziness and two cases of cough were reported in the procedure of treatment , with an incidence rate of 6.7%.Conclu-sionValsartan can significantly decrease the blood pressure and increase the insulin sensitivity in aged patients with ISH with slight side effects.
