Retrospeaive study of intravenous itraconazole in treatment of invasive fungal infec-tion in hematologic malignancies
10.13699/j.cnki.1001-6821.2014.08.001
- VernacularTitle:回顾性分析伊曲康唑注射液治疗恶性血液病侵袭性真菌感染的疗效
- Author:
Da-Quan GAO
1
;
Ya-Ping XIE
;
Shen-Xian QIAN
Author Information
1. 杭州市第一人民医院 血液科
- Keywords:
itraconazole;
mycoses;
hematologic malignancies
- From:
The Chinese Journal of Clinical Pharmacology
2014;(8):659-660,663
- CountryChina
- Language:Chinese
-
Abstract:
Objeetive To investigate the efficacy and safety of long -term intravenous itraconazole for the treatment of invasive fungal infection ( IFI) in patients with hematological malignancies.Methods Sixty -nine patients with above mentioned conditions and diagnosed as IFI was administered at a dose of 200 mg every 12 hours for 2 days and followed by 200 mg every 24 hours at least 14 days.Responses were determined on the basis of clinical and microbiological criteria.Results The total response rates related to itraconazole among the IFI patients were 87.0%(60/69).Adverse effects rates were 18.8%, and 70% adverse effects happened winthin the first 14 days after intravenous itraconazole adminis-tered.Conclusion Long -term intravenous intraconazole antifungal treatment is effective and safe for hematologic malignancies with IFIs.
