Progress in change ofβ1 adrenergic receptor expression on blood pressure
10.13699/j.cnki.1001-6821.2014.07.029
- VernacularTitle:β1肾上腺素能受体表达变化对血压影响的研究进展
- Author:
Lei XIA
1
;
Hong YUAN
;
Xiao-Wei XING
Author Information
1. 中南大学 湘雅三医院 药剂科
- Keywords:
β1 -adrenergic receptor;
hypertension;
β1-AR knockout;
risk factor
- From:
The Chinese Journal of Clinical Pharmacology
2014;(7):653-656
- CountryChina
- Language:Chinese
-
Abstract:
β1 -adrenergic receptor (β1 -AR ) down regulation or knockout may effectively decrease blood pressure in SHR mice.Instead , up regulation of β1-AR would show an opposite effect:increasing heart rate, arrhythmia and hypertension.The research focused on how β1 -AR influence cardiovascular system and the blood pressure in different levels of expressions.This study could help us know more about β1-AR gene and β1 -AR, their functions and the corelation between β1 -AR and blood pressure changes.
