Progress in pharmacokinetics of dexmedetomidine in special populations

VernacularTitle:右美托咪定在特殊人群中的药代动力学研究进展
Author: Ran-Ran ZHANG ¹ ; Guo-Ping YANG ; Qi PEI ; Jin-Fu PENG ; Xi-Ding YANG ; Li LIU
Author Information

1. 中南大学药学院
Keywords: dexmedetomidine; hepatic insufficiency; renal insufficien-cy; pharmacokinetics
From: The Chinese Journal of Clinical Pharmacology 2014;(7):650-652
CountryChina
Language:Chinese
Abstract: Dexmedetomidine , a strong potent and highly selective α2 -adrenoceptor agonist , has an analgesic and dose -dependent sedative property with minimal effects on respiratory depression.It is the only tranquilizing drug which can be arousal currently and is also widely used in clinical applications because of its special pharmacologic characteris-tics.However, dexmedetomidine has large individual differences which made the control of administration dosage more difficult , especially in special populations.So this review article summarized the latest litera-tures about pharmacokinetics of dexmedetomidine in children , the elder-ly , hepatic and renal insufficiency patients and other special populations.