Case analysis of one co-infected atrial fibrillation patient′s adjustment of warfarin dose with the guidance of genotype

VernacularTitle:心房颤动合并感染患者华法林剂量调整的病例分析
Author: Qiu-Fen XIE ¹ ; Qian XIANG ; Ying ZHOU ; Yi-Min CUI
Author Information

1. 北京大学第一医院药剂科
Keywords: atrial fibrillation; infection; warfarin; antibiotic; genotype testing
From: The Chinese Journal of Clinical Pharmacology 2014;(7):639-641
CountryChina
Language:Chinese
Abstract: Objective To provide patients with reasonable individua-lized warfarin anticoagulation therapies according to the genotype testing.Methods Through clinical pharmacists′participation in anticoagulant therapy of an elderly female , who was admitted into hospital for aggrava-tion of heart failure due to atrial fibrillation and pulmonary infection , the reason for the elevated international normalized ratio ( INR ) was ana-lyzed , and the dose of warfarin was adjusted according to genotype results ( CYP2 C9*1/*1 and VKORC1 -1639 GA ).Before discharging her , pharmacist educated the patient so as to enhance self -anticoagulant therapy management.Results and Conclusion The patient's condition was improved.Her INR was 1.46 and in an upward trend before the day of her discharge.Guidance of genotypic testing combined with patients′concomitant diseases , medications, diet et al, could reduce time of INR to reach the target range and also improve the effectiveness and safety of anticoagulant therapy.