Evaluation the safety of Yangwei granules on organs of rats

VernacularTitle:养胃颗粒对大鼠脏器的安全性评价
Author: Ping JIANG ¹ ; Na-Na ZHAO ; Xiao CHEN ; Bin ZHU
Author Information

1. 中国人民解放军第九七医院药剂科
Keywords: Yangwei granules; visceral; toxicity; pathology; transmission electron microscope
From: The Chinese Journal of Clinical Pharmacology 2014;(7):626-628
CountryChina
Language:Chinese
Abstract: Objective To study the toxicity and toxicity degree of Yang-wei granules in rats.Methods SD rats were randomly divided into 4 groups.Bland control group ( was given same bulk of 0.3%CMC-Na ) , three doses of ( 69.0 , 34.5 , 6.9 g · kg -1 ) Yangwei granules groups , daily for up to 90 d, respectively.After the withdrawal of the drug ,the viscera coefficients were calculated.The changes of ultrastructures were detected with transmission electron microscope.Results The part coeffi-cients of organ were abnormal during administration phase.The rats were examined after the cessation of Yangwei granules , the abnormal changes of coefficient were completely recovered. There had no obvious abnormality for the important organ pathology examination during the drugs given and after administration.Conclusion Yangwei granules had no obvious toxicity in rats of main visceral for long -term administration.