Effects of flurbiprofen axetil on percentage of each band power of quantitative pharmaco-electroencephalography in rabbits

VernacularTitle:氟比洛芬酯对兔定量药物脑电图各频段功率百分比的影响
Author: Jia-Wen XU ¹ ; Ya-Mei YU ; Yong-Qing CHANG ; He LI ; Ji-Long GUO ; Ti-Jun DAI ; Dong-Hua SHAO ; Li-Hua HANG
Author Information

1. 徐州医学院麻醉学院
Keywords: flurbiprofen axetil; quantitative pharmaco -electroence-hphalography; mechanism; brain electrical activity
From: The Chinese Journal of Clinical Pharmacology 2014;(7):615-616
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of flurbiprofen axetil on percentage of each band power of quantitative pharmaco -electroence-hphalography ( QPEEG ) in rabbits.Methods Twenty -four healthy rabbits were randomly divided into four groups ( n =6 ): 0.9%NaCl 1 mL· kg -1 group, flurbiprofen axetil 5, 10, and 20 mg · kg -1 groups.The QPEEG and power spectral analysis were adopted to analyze the changes of brain electrical activities before and after the intravenous in-jection of flurbiprofen axetil.Results Compared with the baseline , the percentages of each encephalic region and band power had no significant differences in these four groups ( P>0.05 ).Conclusion Flurbiprofen axetil has no obvious effect on percentage of each band power of quantita-tive pharmaco-electroencephalography in rabbits , suggesting that its site of action is not in the cerebral cortex.It is quite different from the opioid analgesics.