The Correlation of Ovarian Follicular Concentrations of IGF-II, IGFBP-1, and 3 between Cumulative Embryo Score in Patients Undergoing IVF-ET.
- Author:
Hye Eun KWON
1
;
Seok Ho HONG
;
Chong Yol PARK
;
Sung Hoon KIM
;
Hee Dong CHAE
;
Chung Hoon KIM
;
Byung Moon KANG
;
Joo Hyun NAM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
- Publication Type:Original Article ; In Vitro
- Keywords:
IGF-II;
IGFBP-1, 3;
Cumulative embryo score
- MeSH:
Embryo Transfer;
Embryonic Structures*;
Female;
Fertilization in Vitro;
Follicular Fluid;
Humans;
Immunoradiometric Assay;
Insulin-Like Growth Factor Binding Protein 1*;
Insulin-Like Growth Factor Binding Protein 3;
Insulin-Like Growth Factor II*
- From:Korean Journal of Obstetrics and Gynecology
2003;46(5):970-977
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the correlation between the concentrations of insulin-like growth factor-II (IGF-II), insulin-like growth factor binding protein-1, 3 (IGFBP-1, 3) in the follicular fluid and the cumulative embryo score (CES) in the patient who underwent in vitro fertilization and embryo transfer (IVF-ET). MATERIALS AND METHODS: A total of 21 cycles of 18 patients which underwent IVF-ET cycle after controlled ovarian hyperstimulation (COH) were included in this study. Using immunoradiometric assay (IRMA), we measured the concentrations of IGF-II, IGFBP-1, 3 in the follicular fluid. The patients were grouped into the pregnant and non-pregnant group. The concentrations of IGF-II, IGFBP-1, 3 in the follicular fluid were compared between the two groups and the correlations of the follicular concentrations of IGF-II, IGFBP-1, 3 and cumulative embryo score were evaluated. Results were analyzed with Mann-Whitney U test and Spearman's rank correlation coefficient and statistical significance was defined as p<0.05. RESULTS: There were no statistical significance in the follicular concentrations of IGF-II, IGFBP-1, 3 between the pregnant group and non-pregnant group. There were signifiant correlation between the follicular concentration of IGF-II and cumulative embryo score (p=0.001). There might be correlations between the follicular concentration of IGFBP-3, and free IGF-II and cumulative embryo score (p=0.053, p=0.056, respectively). CONCLUSION: The follicular IGF-II and free IGF-II might have an influence to development of good- quality embryos in patients undergoing IVF-ET.
