Experimental study on the effect of adenosine disodium triphosphate on myocardial infarction rats
10.13699/j.cnki.1001-6821.2014.07.008
- VernacularTitle:注射用三磷酸腺苷辅酶胰岛素对心肌梗死动物心功能改善作用的实验研究
- Author:
Ming-Xiang SHAO
1
;
Wei-Ting WANG
;
Chun-Hua HAO
;
Zhuan-You ZHAO
;
Li-Da TANG
Author Information
1. 天津医科大学药学院
- Keywords:
adenosine disodium triphosphate;
myocardial infarction;
myocardial remodeling;
echocardiography;
enalaprilat
- From:
The Chinese Journal of Clinical Pharmacology
2014;(7):584-587
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of adenosine disodium triphosphate(ADT) on myocardial infarction in rats.Methods The a-cute myocardial infarction rat model was induced by ligation of the left anterior descending coronary artery.The model rats were divided into five groups randomly:model group, ADT 1, 2, 4 mg· (kg· d) -1 and enal-aprilat 10 mg· ( kg· d) -1 , and the other 8 rats received sham surgery.The effect of ADT on myocardial infarction rats included left ventricular of configuration , the degree of myocardial hypertrophy and pulmonary ede-ma, scope of myocardial infarction and myocardial remodeling were deter-mined by color Doppler echocardiography , hemodynamic , heart weight , lung water content and the content of collagen type ⅠandⅢafter contin-uous dosing for 30 days.Results Compared with model , ADT can im-prove left ventricular function of myocardial infarction rats , improve sig-nificantly left ventricular ejection fraction significantly , reduce left ven-tricular end-diastolic pressure and cavity size , the lung water content and the range of myocardial infarction , inhibit ventricular remodeling , etc.Conclusion ADT can improve the cardiac function after myocardial infarction in rats.
