Pharmacokinetics of iloperidone tablets in healthy volunteers in China
10.13699/j.cnki.1001-6821.2014.07.007
- VernacularTitle:伊潘立酮片在中国健康志愿者的药代动力学
- Author:
Ya-Ling LV
1
;
Li LIU
;
Lu HUANG
;
Ran-Ran ZHANG
;
Yan WANG
;
Hong-Yi TAN
;
Ye HUA
;
Guo-Ping YANG
Author Information
1. 岳阳市第三人民医院
- Keywords:
iloperidone;
pharmacokinetic;
HPLC-MS/MS
- From:
The Chinese Journal of Clinical Pharmacology
2014;(7):581-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics of iloperidone in healthy volunteers.Methods The study was a random , open, double cycle and cross trial.Sixteen healthy volunteers were randomly divided into two groups (8 volunteers in each group ).A single dose of 1 and 3 mg iloperidone was administrated in each group , respectively.The con-centration of iloperidone in human plasma was determined by HPLC -MS/MS.The main pharmacokinetic parameters were calculated with WinNonlin 6.1.Results The main parameters of a single dose of 1 mg and 3 mg of iloperidone were as follows:t1/2were (54.06 ±49.61 ), and (34.92 ±28.42 ) h,ρmax were (0.72 ±0.33 ), and (7.26 ±4.47 ) ng· mL-1, tmax were (2.04 ±0.66 ), (1.43 ±0.33 ) h, and AUCinf were (14.30 ±7.81 ) and (71.90 ±36.48 ) ng· h· mL-1 , respective-ly.Conclusion The process of iloperidone in the dosage range of 1 to 3 mg fits the nolinear dynamic feature in Chinese healthy volunteers.
