Efficacy of S-1 combined with cisplatin for advanced gastric carcinoma
10.13699/j.cnki.1001-6821.2014.07.005
- VernacularTitle:替吉奥联合顺铂治疗进展期胃癌的疗效
- Author:
Ming YUAN
1
;
Jia-Geng HE
;
La-Ti MU
;
Kai QIN
;
Shao-Xiong NIU
;
Jian-Hua NIU
;
Jian-Ping GONG
Author Information
1. 华中科技大学 同济医学院 附属同济医院普外科
- Keywords:
advanced gastric carcinoma;
chemotherapy;
S-1;
cisplatin
- From:
The Chinese Journal of Clinical Pharmacology
2014;(7):575-576,580
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the short-term efficacy and toxicity of the combination of gimeracil and oteracil porassium ( S-1 ) and cispla-tin in the treatment of advanced gastric carcinoma.Methods Fifty-six patients with advanced gastric carcinoma were randomly divided into two groups with 28 cases in each group.Experimental group was treated with S-1 (60 mg bid d1 -d21) combined with cisplatin (60 mg· m-2 iv d1-d3) with 4 weeks as a cycle.While control group was treated with oxaliplatin (130 mg· m-2 iv d1), tegafur (600 mg· m-2 iv d1-d5), calcium folinate ( 120 mg · m-2 iv d1 -d5 ) with 3 weeks as a cycle.Short-term efficacy and adverse reactions were evaluated after three cy-cles.Results The tumor response rate of experimental group and control group was 75.0%and 42.9%(P<0.05).Besides, compared with the con-trol group , the occurrence of gradeⅢ-Ⅳadverse reactions in experimental group were apparently lower.Conclusion The regimen of S -1 combined with cisplatin has shown a better efficacy in the treatment of patients with ad-vanced gastric carcinoma , and the toxicity is relatively mild and tolerable .
