Study on the anti-inflammatory effect and mechanism of the extract of Scutellaria baicalensis Georgi
10.13699/j.cnki.1001-6821.2014.06.025
- VernacularTitle:黄芩提取物的抗炎作用及其作用机制研究
- Author:
Guang-Wu GAO
1
;
Ling LI
Author Information
1. 荆门市第二人民医院 药剂科
- Keywords:
scutellaria baicalensis Georgi;
anti -inflammatory;
carrag-eenan;
inflammatory mediators;
prostaglandin E 2
- From:
The Chinese Journal of Clinical Pharmacology
2014;(6):550-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti -inflammatory effect of the eth-anolic extract of Scutellaria baicalensis Georgi ( TESB ) and its mecha-nisms.Methods The rat paw edema model was taken by carrageenan -induced.The SD rats were randomly divided into blank group ( 0.9%NaCl ) , model group , positive control group , TESB of the low -dose group, middle dose group and high dose group .The duratoin was 5 days.The effects of TESB on carrageenan -induced production of prosta-glandin E2(PGE2), generation of malondialdehyde(MDA), nitric oxide ( NO) in the inflammatory tissue of rats were observed.Results TESB reduced carrageenan -induced rat paw oedema in dose -dependent man-ner, achieving high degree of anti -inflammatory activity.As compared with model group , TESB significantly inhibited the generation of PGE 2 by 19.6%, 42.9%, 66.1%, respectively; inhibited the generation of MDA by 16.8%, 39.9%, 68.8%, respectively;reduced the increased level of NO by 16.4%, 48.4%, 73.8%, respectively.Conclusion The scutellaria baicalensis Georgi is effective against inflammation , and this effect may be related to the inhibition on lipid peroxidation and in-flammatory mediators.
