Determination of ethaselen concentration in cancer patients plasma and study on its pharmacokinetics

VernacularTitle:建立乙烷硒啉在癌症患者血浆中的浓度测定方法及其药代动力学研究
Author: Kai-Zhi LU ¹ ; Wei YUAN ; Hui GAN ; Zhi-Yun MENG ; Gui-Fang DOU
Author Information

1. 广西医科大学研究生学院
Keywords: ethaselen; ICP -MS; plasma concentration; pharmacoki-netic
From: The Chinese Journal of Clinical Pharmacology 2014;(6):521-523
CountryChina
Language:Chinese
Abstract: Objective To establish inductively coupled plasma mass spectrometry ( ICP -MS ) method for determining the concentration of ethaselen in human plasma , and to apply it to the pharmacokinetic study of ethaselen dispersible tablets.Methods Plasma samples were digested with nitric acid , then detected by ICP -MS method.The main pharmaco-kinetic parameters were calculated with non -compartmental analysis by Wi-nNonlin 5.2 software.Results The parameters pharmacokinetic results of ethaselen were as follows: tmax was ( 9.20 ± 0.98 ) h, Cmax was (597.58 ±221.73) ng· mL-1, AUC0-t was (2.57 ±0.92) ng· h· mL-1, the mean residence time (MRT) was (24.60 ±0.63)h.Conclusion The ICP-MS method is simple, rapid and sensitive, which is suitable for clini-cal determination of the concentration of ethaselen dispersible tablets in hu-man plasma.