Pharmacokinetics of cefazolin sodium pentahydrate injection in beagle dogs
10.13699/j.cnki.1001-6821.2014.06.014
- VernacularTitle:注射用五水头孢唑林钠在比格犬体内药代动力学研究
- Author:
Yan JIANG
1
;
Yang CHU
;
Yi-Fan LUO
;
Ming-Yan JIANG
Author Information
1. 中国医科大学 附属第一医院 药学部
- Keywords:
cefazolin sodium pentahydrate;
HPLC;
pharmacokinetic
- From:
The Chinese Journal of Clinical Pharmacology
2014;(6):514-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the pharmacokinetics parameters of cefazolin sodium pentahydrate and cefazolin sodium in beagle dogs after intravenous injection.Methods Six healthy beagle dogs were involved in the single -dose, double -cycle, randomized, and cross -over study.Six dogs were randomly divided into two groups , and each was given a single dose of 55 mg · kg -1 cefazolin sodium pentahydrate or ce-fazolin sodium in order to study pharmacokinetics of cefazolin sodium in plasma.The washout period lasted for 7 days.Concentrations were deter-mined by HPLC method.The pharmacokinetics parameters were evalua-ted by DAS 2.0 software.Results The main pharmacokinetic parameters of cefazolin sodium test and reference preparations were as follows:t1/2 were (1.34 ±0.15), (1.31 ±0.17 ) h; Cmax were(181.14 ±28.13 ), ( 171.18 ± 24.70 ) μg · mL-1; tmax were ( 0.75 ± 0.10 ) , (0.71 ±0.10) h;AUC0-t were(342.57 ±76.02), (323.33 ±40.59)μg · h · mL-1.Conclusion After single intravenous administration , there are differences between pharmacokinetic parameters of the test and the reference drugs in beagle dogs , such as AUC0-t, AUC0-∞ and Cmax.
