Efficacy and safety of paroxetine combined with quetiapine in the treatment of generalized anxiety disorder
10.13699/j.cnki.1001-6821.2014.06.012
- VernacularTitle:帕罗西汀联合喹硫平治疗广泛性焦虑障碍的疗效与安全性
- Author:
Kai-Yuan ZHANG
1
;
Jian-Fei SHI
;
Guang-Zheng TANG
;
Yun-Hai TAO
;
Bian-Hong SHEN
;
Tong ZHAO
Author Information
1. 安徽医科大学 医学心理系
- Keywords:
generalized anxiety disorder;
paroxetine;
quetiapine
- From:
The Chinese Journal of Clinical Pharmacology
2014;(6):508-510
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of paroxe-tine combined with low dose of quetiapine in the treatment of generalized anxiety disorder.Methods One hundred and forty patients with gener-alized anxiety disorder were randomly assigned to treatment group ( parox-etine combined with low dose of quetiapine group , n =71 ) and control group ( paroxetine group , n =69 ).The efficacy was assessed by the Hamilton rating scale for anxiety ( HAMA ) , the Treatment Emergent Symptom Scale ( TESS ) for side effects , and Pittsburgh sleep quality in-dex(PSQI)for sleep qualities of all participants at baseline and at the end of 1st, 2nd, 4th, 6th, 8thweek.Results There were no significant differ-ences between two groups at cure rate ( 70.4%/68.1%) , notable im-provement rate ( 15.5%/13.0%) , progress rate ( 8.5%/10.1%) , and ineffective rate ( 5.6%/8.7%) overall the treatment course.Compare with the baseline , the treatment group showed notable decrease of HAMA at the 1 st weekend ( P<0.05 ) , and the control group showed that at the 2nd weekend (P<0.05).The treatment group had a more significant de-crease than the control group at the 1st, 2nd, and 4th week end(P<0.05 or P<0.01 ).The psychic anxiety score of the treatment group at the 1st, 2nd, 4th weekend and the somatic anxiety score at the 2nd, 4th weekend showed significant decrease ,compared with the control group ( P<0.05 or P<0.01 ).Both of the two group had no serious adverse events.Conclusion Paroxe-tine combined with low dose of quetiapine is an effective and safe way to treat generalized anxiety disorder , and patients have good compliance under the treatment.
