Effect of the combination of Weifuchun and retinoic acid on the expression of Rb gene and C-erbB-2 gene in the patients with gastric precancerous lesions
10.13699/j.cnki.1001-6821.2014.06.007
- VernacularTitle:胃复春和维 A酸对胃癌前病变患者基因 Rb和C-erbB-2表达的影响
- Author:
Xiao-Lei LI
1
;
Xiao-Qi WANG
;
Hai-Ou QU
Author Information
1. 温岭市第一人民医院 外科
- Keywords:
Weifuchun;
retinoic acid;
gastric precancerous lesions;
Rb;
CerbB-2
- From:
The Chinese Journal of Clinical Pharmacology
2014;(6):493-496
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of the combination of Weifu-chun and retinoic acid on the expression of Rb Gene and C -erbB -2 Gene in the patients with gastric precancerous lesions.Methods One hundred and fifteen patients with gastric precancerous lesions were ran-domly divided into the observed group ( n =60 ) and the control group ( n=60 ).the group were all given omeprazole enteric -coated capsules and hydrotalcite tablets , and at the same time the observed group was ad-ministrated with Weifuchun ( 1.436 g every time , tid ) and retinoic acid (10 mg every time,tid).The expressions of Rb gene and C -erbB-2 gene were detected by immunohistochemistry and compared after 12 months treatment.Results The positive rate of Rb gene after treatment in the observed group(87.93%) was significantly higher than that before treatment in the observed group (68.97%) and after treatment in the con-trol group(71.93%)(P<0.05).The positive rate of C-erbB-2 gene after treatment in the observed group ( 12.07%) was significantly lower than that before treatment in the observed group ( 34.48%) and after treatment in the control group(29.82%)(P<0.05).Conclusion We-ifuchun and retinoic acid could medicate the expressions of gene Rb and C-erbB-2.
