Clinical study of Astragalus combined with 1,6-diphosphate on child viral myo-carditis
10.13699/j.cnki.1001-6821.2014.06.004
- VernacularTitle:黄芪注射液联合1，6-二磷酸果糖对小儿病毒性心肌炎的临床研究
- Author:
Fang GAO
1
;
Yong-Xia WANG
;
Dong-Mei CHU
;
Bao-Li WANG
;
Ling YAO
Author Information
1. 天津市第五中心医院 儿科
- Keywords:
astragalus;
1,6-diphosphate;
viral myocarditis
- From:
The Chinese Journal of Clinical Pharmacology
2014;(6):484-486
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate clinical efficacy and safety of astraga-lus combined with 1,6 -diphosphate in the treatment of pediatric viral myocarditis( PVM) and its effect on cellular immune function of pediatric patients.Methods Eighty-one children with PVM were randomly di-vided into control group ( n=44 ) and experiment group ( n=37 ).Oral mulvital and 200 mg· kg -1 · d-1 of intravenous 1,6-diphosphate were given to children in the control group as the basic treatment.And chil-dren were given 100 mg · kg -1 of astragalus plus 10% glucose 100 mL intravenous as well as the basic treatment of control group.After 3 -week treatment , the total efficacy , side effect and cellular immune func-tion of children were recorded and compared between the two groups.Results The total efficacy of experiment group ( 97.3%) was much higher than that of control group (81.8%)(P<0.05).The cellular im-mune function ( CD3 +, CD4 +, CD8 +and NK cell percentage ) was sig-nificantly improved in children compared with prior -treatment condition ( P<0.05 ) , and a much higher improvement was detected in the experi-ment group ( P<0.05 );the myocardial enzymes ( creatine kinase , crea-tine kinase isoenzyme , and lactate dehydrogenase ) were decreased after treatment, and the experiment group showed a much higher improvement. ( P<0.05 ).Only one patient had rash in the experiment group during the treatment.Conclusion Astragalus com-bined with 1,6-diphosphate has significant clinical efficacy and few side effects in children with viral myocarditis .The cellular immune function of patients can be improved by the combination regimen.
