Clinical study of the effect of clopidogrel on inflammatory factors and prognosis of patients with non ST segment elevation acute coronary syndrome patients
10.13699/j.cnki.1001-6821.2014.06.003
- VernacularTitle:氯吡格雷对非 ST段抬高冠脉综合征患者炎症因子及预后的影响
- Author:
Xiao-Fen XIA
1
;
Xiao-Ying LI
;
Hong-Juan ZHAO
Author Information
1. 临安市人民医院 心血管内科
- Keywords:
non ST segment elevation acute coronary syndrome;
clopidogrel;
inflammatory factor;
cardiac function
- From:
The Chinese Journal of Clinical Pharmacology
2014;(6):481-483
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of clopidogrel on inflammatory factors and prognosis of patients with non ST segment elevationacute coro-nary syndrome ( NSTEACS ).Methods One hundred and twenty pa-tients with NSTEACS in our hospital were enrolled and randomly divided into observation group ( given aspirin combined with clopidogrel ) and control group ( only given aspirin ).Inflammatory factor level and heart function index were detected at pretreatment and 4-week treatment , re-spectively.Results Before treatment , the differences of inflammatory factor level and heart function indexe of two groups had no statistical sig-nificance;after 4 -week treatment , the levels of C -reactive protein ( CRP) ( 4.2 ±0.8 ) vs ( 7.1 ±1.3 ) mg · L-1 and tumor necrosis factor-α(TNF-α) (39.6 ±9.4) vs (66.9 ±11.4) pg· L-1 in ob-servation group were lower than those in control group.The values of E peak (76.4 ±14.9 ) vs (72.1 ±13.6 ) cm· s-1 , E/A (1.4 ±0.2 ) vs ( 1.3 ±0.2 ) , LVEF ( 69.3 ±11.3 )% vs ( 64.1 ±7.5 )%, and LVEDD (58.3 ±7.8 ) vs (54.1 ±8.7 ) in observation group were higher than those in control group.The values of E peak , E/A value, LVEF, LVEDD had negative correlation with the levels of CRP and TNF -α.Conclusion Clopidogrel can effectively decrease the levels of inflammatory factors and improve long -term heart function of patients with NSTEACS.
