Effect of Shenfu injection on cardiac function and ventricular remodeling in patients with dilated cardiomyopathy associated with heart failure
10.13699/j.cnki.1001-6821.2014.06.002
- VernacularTitle:参附注射液对扩张型心肌病心力衰竭患者心功能及心室重构的影响
- Author:
Fang ZHANG
1
;
Kai-Han REN
;
Yu-Lin CHEN
Author Information
1. 杭州师范大学 附属医院 心血管内科
- Keywords:
Shenfu injection;
heart failure;
dilated cardiomyopathy;
brain natriuretic peptide;
angiotensin Ⅱ;
endothelin
- From:
The Chinese Journal of Clinical Pharmacology
2014;(6):478-480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of Shenfu injec-tion on cardiac function of patients with dilated cardiomyopathy ( DCM ) associated with heart failure ( HF ) and its influence on brain natriuretic peptide ( BNP) , angiotensinⅡ( Ang-Ⅱ) , endothelin ( ET-Ⅰ) in plas-ma.Methods Eighty patients with DCM associated with HF were ran-domly divided into treatment group (n=40) and control group (n=40).Patients in the control group were only given conventional treatment of western medicine for two weeks , while patients in the treatment group were treated with Shenfu injection 50 mL on the basis of the conventional treat-ment for two weeks.The cardiac function,6 -minute walk test, and the change of BNP , Ang-Ⅱ, ET-Ⅰwere observed before and after treatment.Results The cardiac function and 6-minute walk test of the Shenfu treat-ment group improved remarkably compared with control group (P<0.05).The levels of BNP , Ang-Ⅱ, ET-Ⅰin both groups decreased significantly after treatment (P<0.05), and that in treatment group decreased more ob-viously compared with control group (P<0.05).Conclusion Shenfu in-jection can improve cardiac function of patients with DCM associated with HF, which also has therapeutic effects on the activation of neuroendocrine.
