Application of Monte Carlo simulation to optimize the dosage regimen of norvancomycin
- VernacularTitle:用蒙特卡洛软件模拟优化去甲万古霉素的给药方案
- Author:
Gan-Bin WU
1
;
Xiang-Yu TIAN
;
Lian-Qi HAO
;
Ying ZHANG
;
Bao-Luo WAN
;
Xiao-Tian LI
;
Mao-Wen GUO
Author Information
1. 郑州大学 药学院
- Keywords:
Monte Carlo simulation;
norvancomycin;
probabilities of target attainment;
cumulative fractions of response
- From:
The Chinese Journal of Clinical Pharmacology
2014;(5):442-444
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess and optimize the dosage regimens of nor-vancomycin in patients with different renal functions.Methods The minimum inhibitory concentration ( MIC ) distribution was determined by agar dilution method with the target value of AUC 0-24/MIC≥638.Ten thousand cases in virtue of Monte Carlo simulation were performed in dif-ferent doses to obtain probabilities of target attainment ( PTA) and cumu-lative fractions of response ( CFR ) in patients with different renal func-tions.Results For the patients with normal renal function , when En-terococcus faecium and Enterococcus faecalis were treated with recommen-ded dose , from 0.8 to 1.6 g· d-1 , the CFR were lower than 59.77%.The CFR could reach to 83.95%and 73.10%when the dose was adjus-ted to 2.5 g· d -1.For the patients with moderate renal function insuffi-ciency , the CFR could reach to 82.81% at the dose of 0.8 g · d -1 against Enterococcus faecalis.The CFR could reach from 73.10% to 86.84%at the dose from 0.8 to 2.5 g · d-1 in the process of treating Enterococcus faecium.For the patients with severe renal function insuffi-ciency , the CFR could reach to 97.77% and 85.90% respectively a-gainst Enterococcus faecalis and Enterococcus faecium.Conclusion Monte Carlo simulation provides dosage regimens and the norvancomycin regimen is complemented and optimized.
