Experimental study on influence of Yiqibuxue granuel on T lymphocyte subsets in rats with syndrome of heart-Qi insufficiency
- VernacularTitle:益气活血颗粒对心气虚证T淋巴细胞亚群影响的实验研究
- Author:
Ge JIN
1
;
Xiao-Li DONG
;
Jing GU
Author Information
1. 甘肃中医学院
- Keywords:
syndrome of heart -Qi insufficiency;
Yiqibuxue granuel;
Tianwangbuxin pill
- From:
The Chinese Journal of Clinical Pharmacology
2014;(5):436-437,472
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of some Chinese herbal granules with the effects of replenishing Qi and activating blood on T lym-phocyte subsets in rats with syndrome of heart -Qi insufficiency.Meth-ods The models were established on rats , which were orally given Yiqibuxue granule with high , low doses ( 2.0 , 0.5 g/100 g ) and Tian-wangbuxin pills (1 g/100 g, control group ) and normal saline respective-ly,once a day for 7 days.The T lymphocyte subsets in peripheral blood and cardiac muscle in rats were observed.Results The model group was lower than the normal saline group on natural kill and wound cell ( CD3+) ,adjuvant T cell ( CD4+) ,higher than normal saline group on cell toxicity T cell( CD8+).There was a significant difference between model group and other groups ( P<0.01 ).There were significant differences ( P<0.01 ) between the high -dose group and the control group.Conclu-sion The Yiqibuxue granules with the effects of replenishing Qi and ac-tivating blood are effective in raising CD 3+、CD4+and reducing CD 8+.
