Clinical efficacy and safety of nicergoline combined with oxiracetam in the treatment of vascular cognitive impairment
- VernacularTitle:尼麦角林与奥拉西坦联合治疗血管性认知功能障碍临床疗效与安全性
- Author:
Sheng-Wu ZHANG
1
;
Li-Ping LU
;
Ya-Nan TANG
Author Information
1. 浙江省丽水市人民医院 神经内科
- Keywords:
nicergoline;
oxiracetam;
vascular cognitive impairment
- From:
The Chinese Journal of Clinical Pharmacology
2014;(5):408-410
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of nicergoline combined with oxiracetam in the treatment of vascular cogni-tive impairment(VCI).Methods One hundred and twenty -two sub-jects with VCI were randomly divided into nicergoline group ( n =38 ) with nicergoline 10 mg, tid po, oxiracetam group ( n=41) with oxirace-tam 800 mg, tid po, and combined group(n=43)with nicergoline plus oxiracetam of the same dose.After three-month treatment , the Mon-treal Cognitive Assessment ( MoCA) and activities of daily living ( ADL) scale were compared before and after the treatment to evaluate the im-provement of cognitive and activities of daily living ability as well as the side effects of the two drugs.Results After 3-month treatment , MoCA score was significantly elevated ( P<0.05 ) and ADL was significantly reduced in all of the three groups ( P<0.05 ) , and the changes in the combined group was much more obvious than those of the other two groups ( P<0.05 ).No obvious side effects were observed in the periods of treatment in all the three groups.Conclusion Combined treatment was superior to either of the single regiment in the treatment of VCI with-out increasing the risk of developing side effects.
