Correlation the gene polymorphism of the multidrug resistance gene and cytochrome P450 2C19 and anticoagulation effects of clopidogrel
- VernacularTitle:多重耐药基因及细胞色素 P450酶2C19基因多态性与氯吡格雷抗凝疗效的关系
- Author:
Hong-Min CAI
1
;
Guan-Ren ZHAO
;
Duan-Hao FENG
Author Information
1. 河北北方学院研究生部
- Keywords:
multidrug resistance gene;
cytochrome P450 2 C19;
genetic polymorphism;
clopidogrel;
gene chip
- From:
The Chinese Journal of Clinical Pharmacology
2014;(5):399-401
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between multidrug re-sistance gene(MDR1)and cytochrome P450 2C19(CYP2C19)gene poly-morphisms and the effect of clopidogrel in patients with acute coronary syndrome ( ACS ) after undergoing percutaneous coronary intervention ( PCI ) .Methods The patients with ACS who were undergoing PCI were divided into three groups according to the result of MA ADP which tests by thromboelastogram ( TEG).Group A consists of patients with MA ADP >47, group B consists of patients with 31≤MAADP≤47 and group C con-sists of patients with MA ADP <31, respectively.The genotype of CYP2C19 is decided by gene chips hybridization and the genotype of MDR1 is decided by gene sequencing.Then the distribution of gene poly-morphism between were compared with different groups.Results There were no significantly differences among three groups in different genotype of MDR1( P>0.05 ).The proportion of patients with poor metabolism of CYP2C19 in group A was higher than the other two groups significantly ( P<0.05).Conclusion CYP2C19 gene polymorphisms affect the an-ticoagulant effect of clopidogrel.
