Meta analysis of comparative study of ziprasidone and clozapine for the treatment of first-episode schizophrenia
- VernacularTitle:齐拉西酮与氯氮平治疗首发精神分裂症的 Meta分析
- Author:
Pei-Li REN
1
;
Li-Juan XU
;
Heng WANG
Author Information
1. 商丘医学高等专科学校,河南 商丘 476100
- Keywords:
ziprasidone;
clozapine;
schizophrenia;
Meta analysis
- From:
The Chinese Journal of Clinical Pharmacology
2014;(4):363-365
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the differences of efficacy and side effects between ziprasidone and clozapine for the treatment of first -epi-sode schizophrenia.Methods Nine comparative studies of ziprasidone and clozapine for the treatment of first -episode schizophrenia were rean-alyzed by meta analysis.Results The significant differences on symp-toms between prior and post treatment were found ( P<0.01 ) .Ziprasi-done was superior to clozapine in improving the total scores of positive and negative syndrome scale ( PANSS ) and the negative symptoms of schizophrenia ( P<0.05 ).The somnolence , constipation , salivation , ab-normal electrocardiogram , weight gain , blurred vision and abnormal liver function in ziprasidone group were significantly less than clozapine group (P<0.05 or P<0.01), but the extrapyramidal symptoms(EPS) in zi-prasidone group was significantly more than that of clozapine group ( P<0.01 ).Conclusion Ziprasidone has an advantage over clozapine in im-proving the total scores of PANSS and the negative symptoms in first -ep-isode schizophrenic , with less adverse drug effects.
