Comparison of the cephalosporins and penicillins on the eradication of Helicobacter pylori by Meta-analysis
- VernacularTitle:比较头孢菌素与青霉素类用于幽门螺杆菌根除的荟萃分析
- Author:
Can LI
1
;
Yingying YAN
;
Suodi ZHAI
Author Information
1. 北京大学 第三医院 药剂科
- Keywords:
penecillin;
cephalosporin;
amoxicillin;
H.pylori
- From:
The Chinese Journal of Clinical Pharmacology
2014;(4):350-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the relative efficacy and safety of cephalosporins or penicillins based H.pylori eradication regimen.Meth-ods Electronic databases were searched to identify the randomized con-trolled trials ( RCTs ) comparing cephalosporins and penecillins for H.pylori eradication.The outcome measure was H.pylori eradication rate , incidence of adverse drug reactions ( ADR) and ulcer healing.Five stud-ies including 513 patients were identified.Results No statistical differ-ence on H.pylori eradication efficacy between cephalosporins and peni-cillins based regimen was shown on Meta -analysis ( P>0.05 ).No se-vere adverse drug reaction ( ADR) was reported in the identified studies , but the incidence of ADR of cephalosporins group was significantly lower than that of penicillin group ( P<0.01 ).Conclusion The efficacy of cephalosporins is similar to penicillins for H.pylori eradication , but cephalosporins have shown a significantly lower incidence of ADR.
