Experimental study on the effect of pharmacodynamics of compound mometasone nasal spray on guinea pig with allergic rhinitis
- VernacularTitle:复方莫米松鼻喷剂对变应性鼻炎的药效学实验研究
- Author:
Xiu-Min LI
1
;
Yu-Peng XIE
Author Information
1. 北京军区总医院 药剂科
- Keywords:
compound mometasone;
allergic rhinitis;
pharmacodynamics
- From:
The Chinese Journal of Clinical Pharmacology
2014;(4):344-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of compound mometa-sone nasal spray on guinea pigs with allergic rhinitis.Methods Forty allergic rhinitis models were built by using 10%toluenediisocyanate olive oil intranasally , which were then divided into four groups randomly: the model group , the blank group , the test-single group and the test -com-bination group.The two test groups were given medicine ( bilateral nasal , with each side 40 μL) at the eighth day after sensitization and an hour before inspiration , respectively.The guinea pigs were administrated 5 consecutive days a week and then suspended the medicine for 2 days.The treatment lasted for 3 weeks.The other two groups were given 0.9%NaCl.The effects of the drug on syndrome score , the amount of eosino-phile granulocytes (EG), pathological changes and the content of nasal histamine were observed.Results The symptoms of allergic rhinitis , the pathological changes and the amount of EG were effectively inhibited or reduced by compound mometasone nasal spray.However , there was no obvious difference between test -combination and test -single groups in contents of histamine in mucosa.Conclusion Compound mometasone nasal spray has a better effect on treating allergic rhinitis in guinea pigs.
