Effect of the combination of anisodamine and fentanyl post-processing against my-ocardial ischemia and reperfusion injury on metabolic indicators of rabbits
- VernacularTitle:山莨菪碱联合芬太尼后处理对兔心肌缺血再灌注代谢指标的影响
- Author:
Wen-Ting ZHANG
1
;
Fang-Jiang LI
;
Xiao-Yuan WANG
;
Qing LI
;
Qiang ZHANG
;
Hui-Xian LI
Author Information
1. 河北北方学院 研究生部
- Keywords:
ischemic postconditioning;
fentanyl;
anisodamine;
superoside dismutase;
manlondialdehyde
- From:
The Chinese Journal of Clinical Pharmacology
2014;(4):337-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of the combination of aniso-damine and fentanyl on metabolic indicators , as well as the two drugs separately combined with myocardial ischemia post -processing against myocardial ischemia and reperfusion injury in rabbits.Methods The pre-ligated left anterior descending coronary artery ( LAD) for 30 min and 120 min of reperfusion were adopted to establish myocardial ischemia-reperfusion model.The 48 Japanese white rabbits were randomly as-signed to six groups ( n=8 each ): Sham-operated group ( group S ) , to separate LAD without ligation; ischemia -reperfusion group ( group I/R ) , to restore reperfusion directly; ischemic postconditioning group ( group IP C ) after 30 min′s ischemia , to give ischemic postconditioning and then to restore reperfusion; fentanyl postconditioning group ( group F), anisodamine postconditioning group ( group A), and a combination of fentanyl and anisodamine postconditioning group ( group F+A):ische-mia for 28 min, and then different doses were injected respectively through ear marginal vein as follows: 5 μg · kg -1 of fentanyl , 5 mg · kg -1 of anisodamine , and the two kind of drugs combined for pharmanic post-processing.After 30 min of ischemia , post conditioning was given and then reperfusion was restrored.Differences in the peripheral metabo-lism of superoxide dismutase ( SOD ) , and malondialdehyde ( MDA ) were detected.Results The group A and group F were equal in the concentration of MDA and the active concentration of SOD ( P>0.05 ) ,but for the concentration of MDA , group F+A was lower than these two groups and group IP C was higher than them.However , in terms of the active concentration of SOD, group F+A was higher than these two groups and group IP C was lower than them (P<0.01) .Conclusion Myocardial ischemic postconditioning combined with fentanyl and anisodamine for the treatment of myocardial reperfu -sion injury was much more effective than the single -drug combination with ischemic postconditioning.
