Experimental study of 7-difluoromethyl-5,4'-dimethoxygenistein on antiatherosclerotic mechanism in atherosclerOsis rabbit
10.3969/j.issn.1001-6821.2010.04.011
- VernacularTitle:7-二氟亚甲基-5,4'-二甲烷氧基异黄酮抗兔动脉粥样硬化机制的实验研究
- Author:
Ji-Liang YOU
1
;
Hong ZHAO
;
Xiao-Yi TANG
;
Zhi-Hong ZHONG
;
Xiao-Hua FU
Author Information
1. 湖南师范大学医学院
- Keywords:
7-difluoromethyl-5,4'-dimethoxygenistein;
genistein:atheroselerosis;
effect mechanism
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(4):283-286
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential antiatherosclerotic mechanism of 7-difloromethyl-5,4'-dimethoxygenistein(dFMGEN)in atherosclerosis rabbits.Methods Thirty two New Zealand rabbits were randomly selected from forty male rabbits to make the atherosclerosis model,while the others were defined as normal controls.After sixty days making for model,the rabbits were divided into four groups:model control group(vehicle solvent 5 mg·kg~(-1) per day),dFMGEN group (dFMGEN 5 mg·kg~(-1) per day),lovastatin group(lovastatin 5 mg·kg~(-1) per day)and genistein group(genistein 5 mg·kg~(-1) per day).They were treated for thirty days.Some indices of serum were detected and compared after feeding for 60 days and treatment for 30 days.Results Comparing with model control group,dFMGEN could significantly reduce the serum ET-1,ox-LDL concentration(P＜0.01),increase the serum NO concentration(P＜0.01).There was no significant difference of the HCY levels in each experimental group.Conclusion dFMGEN has potential antiatherosclerotic effects by affecting release of NO and ET-1 and preventing oxidation of low density lipoprotein.
