Pharmacokinetics of lansoprazole injection after a single dose in Chinese healthy volunteers
10.3969/j.issn.1001-6821.2010.04.006
- VernacularTitle:单剂量静脉滴注兰索拉唑在中国健康人体的药代动力学
- Author:
Chen GAO
1
;
Zhi-Gang ZHAO
;
Yan-Bin SI
;
Hao SUN
;
Teng LIU
;
Xiang-Lin ZHANG
;
Xiao LIU
Author Information
1. 首都医科大学附属北京天坛医院
- Keywords:
lansoprazole;
HPLC-UV;
pharmacokinetics
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(4):263-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics of lansoprazole injection with a single intravenous injection administration using a constant speed in Chinese healthy volunteers.Methods Twelve healthy volunteers were enrolled and each of whom was administered with single dose of 15,30,and 65 mg lansoprazole injection in 3 cross periods.The plasma concentrations of lansoprazole were determined by HPLC-UV.The pharmacokinetic parameters of three dose(15,30,65 mg)lansoprazole were calculated by 3P97 software.Results The plasma concentration-time curve fits two compartment model After single iv dose of 15,30,and 65 mg lansoprazole injection,12 volunteers,the main pharmacokinetie parameters of three doses(15,30,60 mg)lansoprazole were as follows:C_(max) were(1105.65±506.24),(2171.33±799.02),(4070.53±643.04)μg·L~(-1);t_(1/2) were(1.63±0.86),(2.30±2.01),(1.90±1.19)h;AUC_(0-12) were(991.16±814.49),(3495.87±1770.92),(8351.14±2599.90)μg·h·L~(-1) respectively.Conclusion After administration of single-dose lansoprazole,it was safe within the dosage ranged from 15 to 60 mg,and there was no significant difference of physiological disposition between the male and female.
