Pharmacokinetics of biapenem injection after a single dose administration in Chinese healthy subjects
10.3969/j.issn.1001-6821.2010.04.004
- VernacularTitle:中国健康受试者单剂量静脉注射比阿培南的药代动力学
- Author:
Ying ZHOU
1
;
Jun-Yu XU
;
Xia ZHAO
;
Pei-Hong SUN
;
Hui-Lin ZHANG
;
Yi-Min CUI
;
Min ZHAO
;
Yong ZHANG
Author Information
1. 北京大学第一医院
- Keywords:
biapenem;
pharmacokinetic;
HPLC-UV
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(4):255-258
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics and safety in healthy volunteers following intravenous administration of biapenem.Methods Ten healthy volunteers were randomized to administer a single dose of biapenem at 300 and 600 mg,respectively.They were given the other dose after a week.The concentration of biapenem in human plasma and urine were determined by HPLC-UV.The main pharmacokinetic parameters were calculated with WinNonLin.Results The main pharmacokinetic parameters of biapenem after single doses of 300 and 600 mg were as follows C_(max) were(11.33±2.71)and(26.80±5.11)μg·mL~(-1);AUC_(0-tn) were(18.01±4.66)and(42.78±8.81)μg·mL~(-1)·h,respectively.Conclusion The process of biapenem in the dosage range of 300-600 mg fit linear dynamic feature.
