Pharmacokinetics of single-dose astromicin sulfate in Chinese healthy volunteers
10.3969/j.issn.1001-6821.2010.04.003
- VernacularTitle:注射用硫酸阿司米星单剂给药在健康人体的药代动力学
- Author:
Cai-Yun ZHAO
1
;
Yuan LV
;
Min-Ji WEI
;
Pu ZHANG
;
Ming ZHANG
;
Yan LIU
;
Jun MANG
;
Ya-Hong XIA
;
Man ZHANG
;
Tian-Yun LI
;
Yong-Hong XIAO
Author Information
1. 北京大学第一医院
- Keywords:
astromicin sulfate;
pharmacokinetics;
HPLC-fluorescence
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(4):251-254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the pharmacokinetics of single dose of astromicin injection in healthy Chinese volunteers.Methods A randomized,three period cross-over,latin-square design study was conducted.Twelve male volunteers were administrated intravenously 150,200 and 250 mg of astromicin within 0.5 h infusion.The concentrations of astromicin in serum and urine were determinated by precolumn derivatization-fluorescence HPLC method.Results The main pharmacokinetic parameters of three dose(150,200,250 mg)were as follows:C_(max) was(11.27±2.65),(15.83±3.14)and(21.97±3.67)mg·L~(-1);t_(1/2)β was(2.56±0.72),(2.97±1.30)and(2.66±1.39)h;AUC_(0-t)was(30.92±8.49),(39.58±11.57)and(47.31±11.59)mg·h·L~(-1);AUC_(0-∞) was(31.78±8.73),(40.50±11.56)and(48.20±11.95)mg·h·L~(-1);V_c was(11.49±2.61),(10.69±1.52)and (10.20±1.93)L;CL was(5.33±2.03),(5.49±1.51)and(5.68 ±1.35)L·h~(-1),respectively.Urinary recovery rates was(78.75±7.00)%,(78.95±12.57)%and(79.94±10.28)%,respectively.Conclusion The main pharmacokinetic parameters of astromicin in difereneut doses were nearly fit linear dynamic feature,and the drug maily excreted through kidney.
