Comparison on the effects of olanzapine and haloperidol for growth hormonal levels in juvenile younger schizophrenia
10.3969/j.issn.1001-6821.2010.04.002
- VernacularTitle:比较奥氮平与氟哌啶醇对青年精神分裂症患者血清生长激素的影响
- Author:
Ming-Lian ZHANG
1
;
Guo-Zhen YUAN
;
Jian-Jun YAO
;
Yun-Biao ZHANG
;
Yu-Sheng LIU
Author Information
1. 南京医科大学附属无锡精神卫生中心
- Keywords:
schizophrenia;
growth hormone;
olanzapine;
haloperidol
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(4):248-250
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the hormone change after olanzapine and haloperidol treatment for juvenile younger schizophrenia Methods Chemiluminescence immunoassay were used to examine serum level of growth hormone in 51 juvenile younger schizophrenia before and after treatment.The 51 patients were randomly assigned to olanzapine group 29 case,dose was(14±7)mg·d~(-1),and haloperidol group 22 cases,dose was(26±8)mg·d~(-1),the treatment duration Was 8 weeks in both two groups.The 20 healthy volunteers was normal as control group.Results Before treatment the growth hormone level of patients was(2.24±1.32)μg·L~(-1);control group was(2.48±1.67)μg·L~(-1).There was no difference of serum growth hormone level between two groups (P＞0.05).After 8 weeks treatment of olanzapine,the growth hormone level of patients was(2.62±1.40)μg·L~(-1),no significantly higher than(2.30±1.51)μg·L~(-1) before trenatment(P＞0.05).After 8 weeks treatment of haloperidol,the growth hormone level of patients was(1.42±0.87)μg·L~(-1),significantly lower than(2.49±1.10)μg·L~(-1) before trenatment(P＜0.01).Conclusion Haloperidol reduced growth hormone levels in juvenile schizophrenia,while olanzapine had no effect on the growth hormone levels.
