Pharmacokinetics of olopatadine hydrochloride tablets in healthy volunteers
10.3969/j.issn.1001-6821.2010.03.008
- VernacularTitle:盐酸奥洛他定片在健康人体的药代动力学
- Author:
Yuan-Yuan LI
1
;
Guang-Tao HAO
;
Hong-Zhi GAO
;
Hai-Yan LI
;
Heng-Yan QU
;
Ze-Yuan LIU
Author Information
1. 军事医学科学院附属医院
- Keywords:
olopatadine hydrochloride;
HPLC-MS/MS;
pharmacokinctics
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(3):190-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pharmacokinetics of olopata-dine hydrochloride tablets in healthy volunteers. Methods Twelve healthy volunteers were divided into receiving orally a single dose of 5, 10,20 mg olopatadine hydrochloride tablets respectively. The plasma and urinary samples were determined by HPLC-MS/MS. Results The main pharmaeokinetic parameters of three different dosages (5,10,20 mg) were as follows: C_(max) were (76.73±26.61) , (133.61±61.63) and (270.44±115.19) μg·L~(-1); t_(max) were (0.75±0.19), (0.96± 0. 29) and (0. 83±0. 32) h; t_(1/2) were (5.20±2. 47), (6. 82±3.04) and (6.87±3.06) h; AUC_(0-t) were (246.70±66.07), (439. 19± 185.03) and (904.69±300.21) μg·h·L~(-1) and AUC_(0-∞) were (248.36±65.81), (442. 02 ± 186. 46) and (907.49±299. 92) μg·h·L~(-1). Mean of excretory rate of three different dosages (5, 10, 20 mg) was 54. 6%. Conclusion The value of C_(max) and AUC will increase following the increase of the doses. The pharmacokinetic characteristic of olopatadine hydrochloride in Chinese healthy vohmteers were fitted with linear kinetic model. It is showed that the sex-related differences did not exist in the main pharmacokinetic parameters between males and females by analysis of variance.
