Effects of hypertonic saline/hetastarch 40 injection on intracranial pressure and cerebral oxygenation in patients undergoing neurosurgery for supratentorial glioma
10.3969/j.issn.1001-6821.2010.03.007
- VernacularTitle:高渗氯化钠羟乙基淀粉40注射液对颅脑手术患者颅内压及脑氧合的影响
- Author:
Bao-Zhu SUN
1
;
Wen-Bo YI
;
Li-Xia FAN
;
Jin-Gui YU
Author Information
1. 山东大学齐鲁医院
- Keywords:
hypertonic saline hetastarch 40 injection;
intracranial pressure;
cerebral oxygenation
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(3):186-189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hypertonic saline/hetastarch 40 injection (HSH40) on intracranial pressure and cerebral oxygenation in patients undergoing neurosurgery for supratentorial glioma. Methods Thirty adult ASA grade Ⅰ or Ⅱ patients undergoing excision of supratentorial glioma were randomly divided into 2 groups: HSH40 4 mL ·kg~(-1) (trial group, 15 cases) or 20% mannitol 1 g·kg~(-1) (control group, 15 cases) was given intravenously over 15 min when hemodynam-ics was stable. Mean arterial pressure (MAP) , cerebrospinal fluid pres-sure(CSFP) and urine output were measured and recorded at different time-points. Cerebral arterial to jugular venous oxygen content differ-ences (Da-jvO_2) and cerebral oxygen extraction rate (CERO_2) were calculated. Results As compared to their baseline, CSFP significantly decreased from 15 min to 120 min after infusion in the 2 groups, and the reduction at 15 min in trial group was more significant than that in control group. Urine output was significantly lower in trial group than that in control group. Da-jvO_2and CERO_2 significantly decreased and internal jugular venous oxygen saturation(SjvO_2) markedly increased at 60 min, 120 min as compared to their baseline in the 2 groups. Conclusion HSH40 is more effective than 20% mannitol in reducing CSFP and can improve cerebral oxygenation during excision of intracranial tumour.
