Effects of thymosin-α1 on the immunolologic function and clinic efficacy in the in-testinal tuberculosis patients
10.3969/j.issn.1001-6821.2010.03.005
- VernacularTitle:胸腺肽-α1对肠结核患者免疫功能及临床疗效的影响
- Author:
Xu-Feng LIANG
1
;
Hong LIANG
;
Guan-Bao WANG
;
Xiu-Hong JIAO
Author Information
1. 北京市中关村医院
- Keywords:
thymosin-α1;
intestinal tuberculosis;
immunolologic func-tion
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(3):179-182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of T-lymphocyte subsets, NK cells and clinical signification in patients with intestinal tu-berculosis after the treatment of thymosin-al. Methods Sixty-six ca-ses of intestinal tuberculosis patients were treated by thymosin-α1 fol-lowed the basis of conventional anti-TB treatment, while 62 cases as a control group. The frequencies of peripheral blood T-lymphocyte subsets and NK cells were determined by flow cytometry. Results After the end of 12 and 16 weeks, the values of CD3~+ , CD4~+ , CD8~+ , and CD4~+/CD8~+ in trial group exhibited significantly higher than that before treat-ment (P<0.05). NK cells in the end of 8, 12, and 16 weeks showed an ascension too (P < 0. 05). There was no significant difference in the control group after treatment (P > 0. 05). The better clinical efficacy was found in the trial group (P < 0. 05). Conclusion Thymosin-α1 can significantly improve the intestinal immunolologic function in the patient with tuberculosis infection.
