Efficacy and safety of intravenous iron sucrose combined with erythropoietin in the treatment of anemia in maintenance hemodialysis patients
10.3969/j.issn.1001-6821.2010.03.004
- VernacularTitle:蔗糖铁注射液联合红细胞生成素治疗维持性血液透析患者肾性贫血的疗效与安全性
- Author:
Feng DU
1
;
Yan-Qiu WANG
;
Ping HE
;
Xue-Song SU
;
De-Tian LI
Author Information
1. 中国医科大学附属盛京医院
- Keywords:
iron sucrose;
erythropoietin;
renal anemia;
hemodialysis
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(3):175-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and compare the efficacy and safe-ty of intravenous iron sucrose with oral polysaccharide iron complex in erythropoietin treated in maintenance hemodialysis patients. Methods A randomized and controlled clinical study was used. Forty-two mainte-nance hemodialysis patients were derided into two groups, iv group and oral group, and were treated with the intravenous iron sucrose and oral polysaccharide iron complex separately. Results Hemoglobin (Hb) , hemotocrit (Hot), serum ferritin (SF) and transferrin saturation (TSAT) were significantly increased in both groups. However, the increment of these laboratory parameters was significantly higher in iv group than in oral group (P < 0. 05). There were less adverse effects in iv group than in oral group (P < 0.05). Conclusion Intravenous iron sucrose is effective and safety in treating anemic maintenance he-modialysis patients. It may induce Hb level to rise faster with less ad-verse effect.
