In vitro effect of cefoperazone-sulbactam (2:1, 1: 1) combined with minocycline on imipenem-resistant Acinetobacter baumannii clinical isolates

VernacularTitle:头孢哌酮/舒巴坦(2:1,1:1)联合米诺环素对亚胺培南耐药鲍曼不动杆菌的体外抗菌作用
Author: Xu-Zhu MA ¹ ; Yuan LV ; Yun LI ; Jian LIU ; Wei-Wei YANG ; Feng XUE
Author Information

1. 北京大学第一医院
Keywords: A. baumannii; checkerboard; fractional inhibitory concen-tration index
From: The Chinese Journal of Clinical Pharmacology 2010;26(3):167-170
CountryChina
Language:Chinese
Abstract: Objective To determine the in vitro activities and interac-tions of cefoperazone-sulbactam (2: 1, 1:1) combined with minocycline against 39 strains of imipenem-resistant Acinetobacter baumannii. Methods The protocol was designed by checkerboard method and the minimal inhibitory concentrations (MICs) of cefoperazone-sulbactam (2 : 1, 1:1) combined with minocycline against the 39 strains of A. bau-mannii were determined by agar dilution method. The fractional inhibito-ry concentration index (FICI) was calculated according to MIC results. The results of the FICI were interpreted as follows : synergy, FICI ≤0. 5 ; antagonism, FICI > 4 ; no interaction, FICI > O. 5-4. 0. Results No interactions of synergy nor antagonism were found. The FICI were all be-tween 0. 5 and 4. 0 in these two combination groups. Conclusion In our study, the interactions of cefoperazone-sulbactam (2: 1, 1:1) com-bined with minocycline against the 39 strains of A. baumannii showed in-different.