Discussion about therapeutic monitoring of vancomycin in adult
10.3969/j.issn.1001-6821.2010.02.022
- VernacularTitle:成人万古霉素血药浓度监测的探讨
- Author:
Kang-Huai ZHANG
1
;
Tai-Kang HUANG
Author Information
1. 沈阳药科大学
- Keywords:
vancomycin;
therapeutic drug monitoring;
nephrotoxicity
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(2):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Vancomycin is one of important antibiotics against methicillin resistant Staphylococcus aureus(MRSA)infections.Therapeutic monitoring of vancomycin has been advocated to lessen the potential toxicity and to achieve therapeutic concentrations.Reviews of previous articles have recommended the AUC/MIC as the preferred predictive parameter for vancomycin and trough serum concentrations as the most accurate and practical method for monitoring vancomycin effectiveness.Monitoring of serum vancomycin concentrations is useful in preventing toxicity in some patients.Additional clinical experiment is required to promote the safety and efficacy of vancomycin use.
