Pharmacokinetic parameters and its significances in central nervous system
10.3969/j.issn.1001-6821.2010.02.021
- VernacularTitle:中枢神经系统的药代动力学参数及其意义
- Author:
Yi-Ping LIU
1
;
Huan-De LI
Author Information
1. 中南大学,湘雅二医院
- Keywords:
central nervous system;
pharmacokinetic parameter
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(2):154-156
- CountryChina
- Language:Chinese
-
Abstract:
It is popularly accept that blood-brain barrier affects drug transport and distribution.Pharmacokinetic parameters will help us predict the pharmacological action,drug-interactions and adverse reaction.This article reviewed the major pharmacokinetic parameters in central nervous system,such as PS product(permeability surface area product),K_(in) or CL_(in) (influx clearance into the brain),K_(out) or CL_(out) (efflux clearance from the brain),T_(1/2eq,in) (intrinsic brain equilibrium half-life),%ID/g (percent of injected dose per gram brain),K_(p,uu) (unbound brain/unbound plasma concentration ratio at steady state),V_(u,brain) (apparent volume of distribution in brain),T_(1/2,brain) (half time in brain).These pa-rameters describe the aspects of blood-brain permeability and the rate and extent of brain drug delivery.
