Pharmacokinetics of midazolam tablets in Chinese Korean and Han healthy volunteers
10.3969/j.issn.1001-6821.2010.02.009
- VernacularTitle:咪达唑仑片在中国朝鲜族和汉族健康人体内的药代动力学
- Author:
Dong-Ya XIA
1
;
Gui-Fu MAO
;
Tao GUO
;
Chang-Qing YANG
Author Information
1. 沈阳军区总医院
- Keywords:
midazolam;
pharmacokinetics;
HPLC;
Chinese Korean;
Chinese Han
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(2):114-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and compare the pharmacokinetics of midazolam in Chinese Korean and Han healthy volunteers after oral administration.Methods Nine healthy Chinese Korean volunteers and ten healthy Han volunteers were given 15 mg midazolam tablets.The concentration of midazolam in plasma was determined by HPLC method and the pharmacokinetic parameters were calculated by DAS 2.0.1 software.Results The pharmacokinetic parameters of midazolam in Chinese Korean and Han were as follow:t_(max) were(0.63±0.72)and(1.52±0.74)h,C_(max) were(189.03 4±82.05) and (103.11±26.37)μg·L~(-1),t_(1/2) were (3.82±2.33) and (2.96±0.77)h,AUC_(0-12) were (369.75±85.47) and (368.95±103.63)μg·h·L~(-1),AUC_(0-∞) were (403.29±124.28) and (397.29±124.06)μg·h·L~(-1),respectively. Conclusion There is large interindividual variabilities in pharmacokinetic parameters of Chinese Korean and Han healthy volunteers,after administration.There were double peaks in plasma concentration-time profile after oral administration.There is significant difference in the t_(max) and C_(max) between Chinese Korean and Han healthy volunteers.
