Pharmacokinetics of omeprazole in Chinese Muslim and Han nationalities healthy volunteers after a single dose administration
10.3969/j.issn.1001-6821.2010.02.008
- VernacularTitle:单剂量口服奥美拉唑在中国回族和汉族健康人体的药代动力学
- Author:
Tao GUO
1
;
Zuo-Ming SUN
;
Dong-Ya XIA
;
Yi ZHENG
;
Yong XIAO
;
Ning-Qin WANG
;
Hong-Liang GUO
;
Peng LIU
Author Information
1. 沈阳军区总医院
- Keywords:
omeprazole;
RP-HPLC;
pharmacokinetics;
Chinese Han;
Chinese Hui
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(2):110-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics of omeprazole tablets in Chinese Hui and Han healthy volunteers.Methods Twenty volunteers were involved in the study,including ten Chinese Hui volunteers and ten Han volunteers.Each healthy volunlteers were given asingle oral dose(40 mg)of omeprazole tablet.The concentration of omeprazole in plasma was determined by RP-HPLC and the pharameters were calculated by DAS 2.0 software.Results The main pharmacokinetic parameters of Chinese Hui and Han were as follows:C_(max) were (941.94±446.08) and (760.49±581.23) μg·L~(-1);t_(max) were(2.7±0.68)and(2.70±0.82)h;t_(1/2) were(2.43±2.83)and(1.60±1.28)h;AUC_(0-12) were (2.29±1.12)and(1.44±7.98)mg·h·L~(-1);AUC_(0-∞) were (2.33±1.11)and(1.47±7.69)mg·h·L~(-1),respectively.Conclusion Individual difference is significant in C_(max),AUC_(0-12),AUC_(0-∞) after an oral omeprazole,but the pharmacokinetic parameters obtained from the results of ststistical analysis show no significant difference in the main pharmacokinetic of omeprazole between Chinese Hui and Han.
