Establish the population pharmacokinetics model of azithromycin in Chinese healthy volunteers
10.3969/j.issn.1001-6821.2010.02.007
- VernacularTitle:建立阿奇霉素在中国健康人群中的群体药代动力学模型
- Author:
Xing-Yi ZHANG
1
;
Ya-Nan ZHAO
;
Yue-Ran WANG
;
Qiang ZHANG
;
Wei LU
Author Information
1. 沈阳药科大学
- Keywords:
azithromycin;
population pharmacokinetics model;
NONMEM
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(2):106-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a population pharmacokinetics model of azithromycin in Chinese population.Methods Based on the dataset from a bioequivalence study held in the Chinese healthy volunteers,the nonlinear mixed effect model of azithromycin oral formulations was constructed by the NONMEM program.The pharmacokinetic parameters and the relationship between the inter-individual effects and fixed effects were estimated.Resuits A two compartment model with firstorder absorption and elimination was established.The body weight affects the CL_1 and CL_2,and age affects the V1 evidently.Conclusion A nonlinear mixed effect model for oral azithromycin formulations Was developed for the Chinese healthy population.
