Relationship between pharmacokinetics and pharmadynamics of mycophenolic acid in liver transplant recipients
10.3969/j.issn.1001-6821.2010.02.006
- VernacularTitle:霉酚酸在肝移植受者的药代动力学与药效学相关性研究
- Author:
Gui-Yang ZHANG
1
;
Min-Min SHI
;
Wei-Xia ZHANG
;
Zhi-Dong GU
;
Hua-Rong MAO
;
Hao CHEN
Author Information
1. 上海交通大学医学院附属瑞金医院
- Keywords:
mycophenolate mofetil;
mycophenolic acid;
pharmacokinetics;
pharmadynamics;
liver transplantation
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(2):102-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between pharmacokinetics and pharmadynamics of mycophenolic acid(MPA)in liver transplant recipients.Methods Plasma MPA concentration were determined EMIT method before MMF dose and after dosing in 20 liver transplant patients received mycophenolate mofetil(MMF).The inhibitory capacity of serum MPA on proliferation of CEM cells was also monitored at 0,1 h and 2 h.Results The rate of proliferation of CEM cells before MMF administration was higher significantly than those at 1 h and 2 h after dosing (P<0.05).The concentrations of MPA at 1 h and 2 h were conversely related with the rate of proliferation of CEM cells(P<0.05).Conclusion After MMF dose,the inhibitory capacity of serum MPA on proliferation of CEM cells was enhanced significantly.This effect was related greatly to MPA concentrations.
