Comparison of effect on blood glucose variability of intravenous infusion of low dosage fructose and glucose in type 2 diabetic patients in stable phase
10.3969/j.issn.1001-6821.2010.02.004
- VernacularTitle:比较小剂量果糖和葡萄糖注射液对2型糖尿病患者稳定期血糖波动的影响
- Author:
Hua-Wen WANG
1
;
You-Shuo LIU
;
Jia-Hua ZHU
;
Yan-Jiao WANG
;
Wu HUANG
;
Hong-Feng ZHAO
Author Information
1. 中南大学湘雅二医院
- Keywords:
fructose;
type 2 diabetes mellitus;
blood glucose fluctuation;
continuous glucose monitoring system
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(2):96-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect of intravenous infusion of low dosage fructose with glucose infusion on blood glucose variability in type 2 diabetic patients in stable phase.Methods Data of 22 patients (male:female,18:4)with type 2 diabetes mellitus in stable phase were collected for the study.From 9am to 11 am,all the subjects were administrated one of the following solutions at constant speed on consecutive days randomly:5% glucose injection 200 mL with insulin 3 U,0.9% normal saline 200 mL or 5%fructose injection 200 mL. The blood glucose concentrations were detected every 5 minutes after infusion by confinuous glucose monitoring system(CGMS).The variability of blood glucose was compared using these 3 kinds of solutions.A two-tailed P value of ≤0.05 was considered statistically significant. Statistical analysis was carried out with SPSS version 13.0.Results No significant difference was found among these 3 kinds of solutions.In addition,no adverse effects were founded.Conclusion Low dosage infusion of neither fructose nor glucose had apparent effect on blood variability of patients with type 2 diabetes mellitus in stable phase.
