Comparison of the clinical effects of intravenous or oral iron on renal anemia in patients with maintenance hemodialysis effects
10.3969/j.issn.1001-6821.2010.02.003
- VernacularTitle:静脉与口服铁剂比较对维持性血透患者肾性贫血的临床疗效
- Author:
Ji-Sheng ZHANG
1
;
Xiao-Qing YOU
;
Ting LIU
;
Yuan-Ping LIU
;
Wen-Bo GAO
;
Bei-Yan BAO
Author Information
1. 宁波市泌尿肾病医院
- Keywords:
renal anemia;
intravenous iron;
erythropoietin
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(2):93-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the therapeutic effects and adverse reactions between intravenous and oral iron,and the effects of erythropoietin (EPO)in patients with chronic renal failure.Methods Between November,2007 and October,2008,48 patients with renal anemia were randomized into 2 groups:intravenous group and oral group,24 in each.The duration of administration lasted for 10 weeks.All patients received regular EPO,with the dose of 100U·kg~(-1),per week. If the patient's hemoglobin (Hb) was more than 100 g·L~(-1),then the dose of EPO decreased by 50%.If the patient's Hb was more than 120 g·L~(-1),then the dose decreased by 75%.The levels of Hb,hematoerit,serum ferritin,adverse reaction and dose of EPO before and 4 weeks,8 weeks and 10 weeks after the administration were observed.Results The levels of Hb,Hematocrit (Hct)and ferritin(SF)in both groups after administration increased compared with before administration;and there was significant difference between the intravenous group and the oral group(P<0.01).The dosages of EPO in both groups after administration were lower than before administration,whereas the dosage in the intravenous group decreased significantly(P<0.05).In the intravenous group,the adverse reactions were significantly lower and the effect of EPO was significantly higher than in the oral group.Conclusion The intravenous iron can not only supply the iron the patients with renal anemia needed,but also increase the effect of EPO and reduce the dosage of EPO.The adverse reactions of intravenous iron are lower and it is safe and convenient.
