Efficacy and safety of loratadine paracetamol and pseudoephedrine sustained release tablets in the treatment of common cold and influenza
10.3969/j.issn.1001-6821.2010.02.002
- VernacularTitle:氯酚伪麻缓释片治疗普通感冒和流行性感冒的疗效和安全性
- Author:
Ya-Hong CHEN
1
;
Wan-Zhen YAO
;
Guang-Fa WANG
;
Zhao-Long CAO
;
Jiang-Tao LIN
;
Liang-An CHEN
Author Information
1. 北京大学第三医院
- Keywords:
loratadine paracetamol and pseudoephedrine sustained-re-lease tablets;
compound pseudoephedrine hydrochloride;
common cold;
influenza
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(2):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of the loratadine paracetamol and pseudoephedrine(LPP)sustained-release tablets in the treatment of common cold and influenza compared with compound pseudoephedrine hydrochloride tablets.Methods Multi-center,randomized,double-blinded controlled clinical trial.One hundred eighteen patients were given LPP sustained-release tablets as trial group,119 were given pseudoephedrine hydrochloride as control group.Results Non-inferiority statistics showed that the improvement rate of clinical symptoms in trial group were not lower than that in control group(P<0.05).The total symptom score did not differ in trial group and control group(P>0.05).The effective rate in trial group and control group were 96.33% and 96.36%(P>0.05).The incidence of adverse drug reactions in trial group and control group was 7.02% and 11.82%,respectively(P>0.05).Conclusion LPP sustained-release tablets is effective and safe in the treatment of common cold and influenza.
