Development of population pharmacokinetics in clinical individual dosage of sirolimus
10.3969/j.issn.1001-6821.2010.01.018
- VernacularTitle:群体药代动力学用于西罗莫司个体化给药研究进展
- Author:
Ling XUE
1
;
Li-Yan MIAO
Author Information
1. 苏州大学附属第一医院
- Keywords:
sirolimus;
individual dosage;
population pharmacokinetics;
immunosuppressive agent;
polymorphism
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(1):71-74
- CountryChina
- Language:Chinese
-
Abstract:
Sirolimus that is a new immunosuppressive agent has been ap-proved for preventing rejection after solid organs transplantation in clini-cal the setting.The article reviews some variability,e.g.demographic characteristics,incorporated drug,blood and biochemical indicator,the polymorphism of CYP3A5,hepat-and kidney function and other factors,that influence the parameters of sirolimus population pharmacokinetics (PPK)through refering a great quantity internal and overseas literatures.
